New Step by Step Map For pkrrating
The interfacial residues are extremely conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a design in which activating RNA serves to be a scaffold to bind many PKR monomers, expanding the nearby